Many are only aware of the meme based on the very first two panels of this 12-panel sequence from the comic series "Gunshow". If you haven't read it, here's a suggestion to get thine arse over there, as K.C.'s work is universally weird & excellent. Anyway, the original page is like this:

(right-click as needed)

(source)

Oh, and the character's name is "The Question Hound" who recurs fairly often in the strip across its 900-comic run. Question Hound is basically the avatar of that whole series.

And... the second, 8-panel sequence, even lesser seen is:

(source)

Btw, if anyone knows the editor of the OC, please drop a comment and I'll update the info.