It would be nice having native programs. At least you can use any native xmpp app with the same account to do text, audio, and visual comms (including groups). The only thing they don't support is the actual social feeds/posts aspect (and soon spaces!).

oh yes, guix+hurd is only x86

Yes!

https://guix.gnu.org/manual/1.5.0/en/html_node/GNU-Distribution.html

I love ipv6 but I don't see how it is related to anything here

Yes your description is just right and is the heart of my question. To use your terminology:

Currently:

• Away from home: Phone -> VM -> Home Server
• At home: Phone -> VM -> Home Server (inefficient!)

Ideally:

• Away from home: Phone -> VM -> Home Server
• At home: Phone -> Home Server

In the ideal case, I would never have to change anything about the wireguard config/status on the Phone, nor would I have to change the domain name used to reach the resource on the Home Server.

Oh hm I didn't think about your last point, maybe it's not really an issue at all. I think I'm not 100% on how the wireguard networking works.

Suppose I tunnel all of my traffic through wireguard on the remote server. Say that while I am home, I request foo.local, which on the remote server DNS maps to a wireguard address corresponding to my home machine. The remote will return to me the wireguard address corresponding to the home machine, and then I will try and go to that wireguard address. Will the home router recognize that that wireguard address is local and not send it out to the remote server?